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Natures Paul Keirn

Basilic thaï (Perilla frutescens), shiso : analyse phytopharmacologique

11 Juillet 2015 , Rédigé par Paul Keirn

Chemicals


(2E,4E,63)-ALLOFARNESENE Plant:
No activity reported.
(2Z,4E,63)-ALLOFARNESENE Plant:
No activity reported.
ALPHA-BERGAMOTENE Plant:
No activity reported.
ALPHA-PINENE Plant:
Allelochemic; Allergenic; Antiacne; Antibacterial; Antifeedant; Antiflu; Antiinflammatory 500 mg/kg; Antipneumonic; Antiseptic; Antispasmodic; Antistaphylococcic; Antiviral; Cancer-Preventive; Coleoptophile; Expectorant; FLavor FEMA 15-150; Herbicide IC50=30 uM; Insecticide 0.82 uM/fly; Insectifuge 50 ppm; Insectiphile; Irritant; P450-2B1-Inhibitor IC50=0.087 uM; Perfumery; Pesticide; Sedative; Spasmogenic; Tranquilizer; Transdermal


AMYGDALIN Leaf:
Antiinflammatory; Antispasmodic; Antitussive; Bitter; Cancer-Preventive; Cyanogenic; Expectorant; Toxic


APIGENIN Seed:
11B-HSD-Inhibitor; AntiADD; Antiaflatoxin IC50=2.57 ppm IC50=9.52 uM; Antiaggregant; Antiaging; Antiallergic; Antiangiogenic 4 uM; Antiarrhythmic; Antibacterial; Anticancer (Lung); Anticomplementary; Antidermatitic; Antiestrogenic; Antiherpetic 20-54 ug/ml; Antihistaminic IC50=10-35 uM; AntiHIV IC50=143 ug/ml IC72=200 ug/ml; Antiinflammatory = indomethacin IC~65=1,000 uM; Antileukemic 20-50 uM; Antimelanomic 1-50 uM; Antimetastatic; Antimutagenic ID50=0.55 ug/ml ID50=10-40 nM; Antioxidant 1.5 x Vit. E IC28.5=62.5 ug/ml; Antiperistaltic; Antiproliferant 1-50 uM IC50=155 uM; Antispasmodic EC50=1-5 uM; Antistress 10 mg/kg; Antithyroid; Antitumor 1-50 uM; Antitumor (Breast); Antitumor (Lung); Antitumor (Skin); Antiviral 20-54 ug/ml; Anxiolytic 10 mg/kg; Apoptotic 12-60 uM; Aromatase-Inhibitor IC65=1 uM/l; Beta-Glucuronidase-Inhibitor IC50=~40 uM; Calcium-Antagonist?; Cancer-Preventive; Choleretic; CNS-Depressant; COX-1-Inhibitor IC65=1,000 uM; COX-2-Inhibitor <40 uM IC50=<15 uM IC>65=1,000 uM; Cyclooxygenase-Inhibitor; Cytochrome-P450-1A1-Inhibitor; Cytotoxic 1-50 uM IC50=9.5 uM IC88=10 ug/ml; Deiodinase-Inhibitor; Differentiator IC40=40 uM MIC=30 uM; Diuretic; DNA-Protective; Estrogenic 16% genistein EC50=0.1-25 uM/l EC50=1 uM; HIF-1alpha-Inhibitor; Hyaluronidase-Inhibitor IC50+=50-250 uM; Hypotensive; ICAM-1-Inhibitor; IKK-Inhibitor; iNOS-Inhibitor IC50=<15 uM; Inotropic; Interleukin-6-Inhibitor; MAO-Inhibitor; MAPK-Inhibitor; Musculotropic; Mutagenic; Myorelaxant; NADH-Oxidase-Inhibitor; NF-kB-Inhibitor; NO-Synthase-Inhibitor 5-50 uM; Nodulation-Signal; Ornithine-Decarboxylase-Inhibitor; P21-Inducer 10-70 uM; Pesticide; PKC-Inhibitor IC50=10 uM; Polyamine-Synthesis-Inhibitor; Progestational; Protein-Kinase-C-Inhibitor IC50=10-40 uM; PTK-Inhibitor 10-100 uM; Quinone-Reductase-Inducer 20 uM; Radioprotective; Sedative 30-100 mg/kg; Sunscreen; TNF-alpha-Inhibitor IC50=3.27 uM; Topoisomerase-I-Inhibitor; Topoisomerase-II-Inhibitor 50 ug/ml IC28=18 uM IC45=180 uM; Uterotrophic EC50=0.1-25 uM/l; Vasodilator; VEGF-Inhibitor IC50=2-7 uM; Xanthine-Oxidase-Inhibitor 0.36 uM


BETA-CARYOPHYLLENE Plant:
No activity reported.


CAFFEIC-ACID Plant:
Aldose-Reductase-Inhibitor 4 ug/ml (weak activity); Allergenic; Analgesic; Antiadenoviral; Antiaggregant; Antiaging; Antiatherogenic; Antibacterial; Anticancer; Anticarcinogenic; Antidepressant; Antiedemic; Antielastase IC50=86 ug/ml (475 uM) IC50=93 um/l; Antiescherichic; Antiflu; Antigonadotropic; Antihemolytic 25 uM; Antihepatoadenomic 200 ppm diet orl mus; Antihepatotoxic; Antiherpetic 50 ug/ml EC50=>50 ug/ml; Antihistaminic; AntiHIV EC50=200 ug/ml; Antihypercholesterolemic; Antihyperthyroid; Antiinflammatory; AntiLegionella; Antileukemic; Antileukotriene; Antimelanogenic; Antimutagenic; Antinitrosaminic; Antiophidic; Antioxidant 1.3 x Vit. E 1/2 BHA 1/3 quercetin 30 mM 50 uM IC57=30 ppm; Antiperoxidant IC35=200 ug/ml IC50=44 uM IC85=100 ug/ml; Antiproliferant; Antiprostaglandin; Antiradicular 1/3 quercetin 10 uM 30 mM IC50=32-35 uM; Antiseptic; Antispasmodic EC50=3.4-15 uM; Antistaphylococcic; Antistomatitic; Antisunburn; Antithiamin; Antithyroid; Antitumor 200 ppm diet orl mus; Antitumor (Skin); Antitumor-Promoter IC42=10 uM; Antiulcerogenic; Antivaccinia; Antiviral IC50=62.5 ug/ml; Anxiolytic; Calcium-Antagonist IC50=1.2 uM rbt; Cancer-Preventive; Carcinogenic 2% (diet); Chemopreventive; Cholagogue; Choleretic; Clastogenic; CNS-Active; Co-carcinogenic; Collagen-Sparing; COX-2-Inhibitor IC32=100 uM; Cytoprotective; Cytotoxic TC50=200 ug/ml; Diuretic; DNA-Active; DNA-Protective; Fungicide MIC=0.4 mg/ml; Hepatocarcinogenic 400 ppm diet orl mus (in the absence of alcohol); Hepatoprotective; Hepatotropic; Histamine-Inhibitor; Immunostimulant; Insectifuge; Leukotriene-Inhibitor; Lipoxygenase-Inhibitor IC27=5 mM IC50=62-148 uM; Lyase-Inhibitor IC50=94-164 uM; Metal-Chelator; Ornithine-Decarboxylase-Inhibitor; Pesticide; Prooxidant; Prostaglandigenic; Sedative 500 mg; Sunscreen IC50=2.5 mg/l IC91=5 mg/l IC98=25 mg/l; Tumorigenic; Vulnerary; Xanthine-Oxidase-Inhibitor IC50=39.21 uM


CITRAL Plant:
Allergenic; Antiallergenic; Antiallergic; Antianaphylactic; Antibacterial; Anticancer; Antihelicobacter; Antiherpetic; Antihistaminic; Antiinflammatory; Antileishmanic; Antioxidant; Antiseptic 5.2 x phenol; Antishock; Antispasmodic; Antitumor; Antitumor (Colon); Antitumor (Liver); Antitumor (Skin); Antiulcer; Antiviral; Apoptotic; Barbituate-Synergist; Bronchorelaxant; Calcium-Antagonist; Cancer-Preventive; Carcinogenic; Caspase-3-Inducer; Chemopreventive; Cytotoxic; Estrogenic; Expectorant; FLavor FEMA 4-170; Fungicide MIC 625 ug/ml; Glaucomagenic; Glutathionigenic; Herbicide IC50=115 uM; Myorelaxant 200 mg/kg; Nematicide IC52=100 ug/ml MLC=100-260 ug/ml; NF-kB-Inhibitor; NO-Inhibitor; P450-2B1-Inhibitor IC50=1.19 uM; Perfumery; Pesticide; Prostatitigenic 185 mg/kg/day/3 ms; Sedative 1 mg/kg ED 1-32 mg/kg; Teratogenic; Trichomonicide LD100=150 ug/ml; Trypanocide; Tyrosinase-Inhibitor ID50=1,500 uM ID50=1.5 mM


CYANIDIN-3,5-DIGLUCOSIDE Leaf:
No activity reported.


DELPHINIDIN Leaf:
Allelochemic IC81=1 mM; Allergenic; Antioxidant ID50=0.7-2.4 uM; Cancer-Preventive; Metal-Chelator (Copper); NO-Inhibitor IC78=250 uM; Pesticide; Pigment; Prooxidant


DILLAPIOL Leaf 2,200 - 3,400 ppm
Antibacterial MIC=45.9->50 nM; Insecticide; Insecticide-Synergist; Molluscicide; Pesticide; Sedative ED50=1.57


ELEMICIN Leaf 2,500 - 3,200 ppm
Antiaggregant IC50=360 uM; Antidepressant ihl; Antifeedant; Antihistaminic; Antiserotonic; Antistress; DNA-Binder; Fungicide MIC=8 ug; Hallucinogenic; Hypotensive ihl; Insecticide 100 ppm; Insectifuge; Larvicide; Neurotoxic; Pesticide; Schistosomicide


ELSHOLTZIAKETONE Plant:
No activity reported.


FURYLKETONE Plant:
No activity reported.


GERANYL-PYROPHOSPHATE Plant:
No activity reported.


ISOEGOMAKEKETONE Plant:
No activity reported.


LIMONENE Plant:
Acaricide LC100=8 uM; AChE-Inhibitor; Allelochemic; Allergenic 1/20th carene; Antiacetylcholinesterase IC22-26=1.2 mM; Antiadenomic; Antialzheimeran?; Antiasthmatic; Antibacterial; Anticancer; Antiesophagitic; Antifeedant; Antiflu; Antiinflammatory; Antilithic; Antilymphomic; Antimetastatic (Stomach); Antimutagenic; Antiobesity; Antiseptic; Antispasmodic ED50=0.197 mg/ml; Antitumor; Antitumor (Breast); Antitumor (Colon); Antitumor (Pancreas); Antitumor (Prostate); Antitumor (Stomach); Antiviral; Apoptotic; Bronchoprotectant; Cancer-Preventive; Candidistat; Chemopreventive; Cholesterolytic; Detoxicant; Enterocontractant; Expectorant; FLavor; Fungiphilic; Fungistat; GST-Inducer; Herbicide IC50=45 uM; Histaminic; Immunomodulator; Insecticide 0.37 uM/fly; Insectifuge; Interleukin-6-Inhibitor; Irritant; Lipolytic; Myorelaxant 50 mg/kg; Nematicide IC=100 ug/ml; NO-Genic; Ornithine-Decarboxylase-Inhibitor ~750 mg/kg (diet); Ozone-Scavenger; P450-Inducer; Peristaltic; Pesticide; Photosensitizer; Sedative ED=1-32 mg/kg; Transdermal


LINALOL Plant:
No activity reported.


LUTEOLIN Leaf: Seed:
Aldose-Reductase-Inhibitor EC=3 ppm IC50=0.45 uM rat; Antiallergic; Antiangiogenic IC60-75=10 uM; Antiatherogenic; Antibacterial MIC=500 ug/ml; Anticarcinogenic; Anticarcinomic; Anticataract EC=3 ppm; Anticomplementary; Antidermatic; Antiestrogenic; Antifeedant IC52=<1,000 ppm diet; Antiherpetic 11-23 ug/ml; Antihistaminic <10-15 uM; AntiHIV; Antiinflammatory =indomethacin; Antileukemic 20-50 uM; Antilymphomic; Antimelanomic; Antimutagenic ID50=0.44 ug/ml ID50=2-5 nM; Antinociceptive; Antioxidant IC50=10 uM; Antipolio; Antiproliferant; Antispasmodic; Antitumor 1-50 uM; Antitumor (brain); Antitumor (Colon); Antitumor (Kidney); Antitumor (Lung); Antitumor (Ovary); Antitumor (Pancreas); Antitumor (Skin) 20 uM; Antitumor (Stomach); Antitumor (Thyroid) 12-50 uM; Antitussive; Antiviral 11-23 ug/ml; Aphidifuge; Apoptotic 12-50 uM; Aromatase-Inhibitor IC35=1 uM/l; Beta-Glucuronidase-Inhibitor IC50=~40 uM; Calcium-Antagonist IC50=1.2 uM rbt; Cancer-Preventive; Chemopreventive; Choleretic; Cytotoxic 1-50 uM; Deiodinase-Inhibitor; Differentiator IC>40=40 uM; Diuretic; Estrogenic 58% genistein; Hepatoprotective; Hyaluronidase-Inhibitor IC50+=100-250 uM; Hypocholesterolemic; ICAM-1-Inhibitor; IKK-Inhibitor; iNOS-Inhibitor; Iodothyronine-Deiodinase-Inhibitor; Lipoxygenase-Inhibitor; MAPK-Inhibitor; Metalloproteinase-Inhibitor; MMP-9-Inhibitor 20 uM; Myorelaxant; NEP-Inhibitor IC50=>42 uM; NF-kB-Inhibitor; NO-Inhibitor; Pesticide; Proliferant; Prostaglandin-Synthetase-Inhibitor; Protein-Kinase-C-Inhibitor IC70=50 uM; PTK-Inhibitor 10-100 uM; Succinoxidase-Inhibitor; TNF-alpha-Inhibitor IC50=14.44 uM; Topoisomerase-I-Inhibitor; Vasodilator; VEGF-Inhibitor IC50=2-7 uM; Xanthine-Oxidase-Inhibitor IC50=0.11 ug/ml


MYRISTICIN Leaf 300 - 3,800 ppm
Amphetaminagenic; Anesthetic; Antiaggregant IC50=250 uM; Antidepressant; Antiinflammatory; Antioxidant 25-100 mg/kg/orl; Antispasmodic; Antistress ihl; Calcium-Antagonist IC50=63.1 gpg (weak activity) IC50=88 uM; Cancer-Preventive 10 mg/mus/orl/day; Diuretic; FLavor FEMA 0.1-10; Fungicide MIC=20 ug; Hallucinogenic; Hepatotoxic; Hypnotic; Hypotensive ihl; Insecticide 25 ppm; Insecticide-Synergist; Larvicide; MAO-Inhibitor; Neurotoxic; Oxytocic; Paralytic; Pesticide; Psychoactive; Sedative 300 mg/kg ipr; Serotoninergic 1,000 ppm orl; Tachycardic; Uterotonic


NAGINATAKETONE Plant:
No activity reported.


PERILLALDEHYDE Plant 400 - 825 ppm
Acaricide; Antibacterial MIC=500->1,000 ug/ml; Antimelanomic IC50=120 uM/l; Antiproliferative; Antiseptic; Candidicide MIC=500 ug/ml; Fungicide MIC=250-500 ug/ml; Mutagenic; Nematicide MLC=1 mg/ml; Sedative; Vibriocide 250 ug/ml


PERILLANIN-CHLORIDE Plant:
No activity reported.


PERILLARTINE Plant:
No activity reported.


PHENYLPROPANOIDS Plant:
No activity reported.


PROTOCATECHUIC-ACID Leaf:
Allergenic; Alpha-Glucosidase-Inhibitor; Antiarrhythmic; Antiasthmatic; Antibacterial; Anticlastogen; Antihepatotoxic; Antiherpetic; Antiinflammatory; Antiischemic; AntiLegionella; Antileukemic; Antimelanogenic ID60=0.5 uM/ml; Antimutagenic; Antiophidic; Antioxidant 1/2 BHT 10 x alpha-tocopherol 2/3 quercetin; Antiperoxidant IC50=>100 uM IC75=200 ug/ml; Antiradicular; Antiseptic; Antispasmodic EC50=4.6-17 uM; Antitumor (Colon); Antitumor (Mouth); Antitumor (Skin); Antitussive; Antiviral; Apoptotic; Carcinogenic; Cardioprotective; Chemopreventive 100 ppm orl rat; Fungicide 500 ug/ml; Glutathione-Depleting; Hepatotoxic; Immunostimulant; Nephrotoxic; Pesticide; Phagocytotic; Prostaglandigenic; Secretogogue; Tyrosinase-Inhibitor ID60=0.5 uM/ml; Ubiquiot


PRUNASIN Leaf:
Aldose-Reductase-Inhibitor 0.1 mM/l rat; Cyanogenic


QUERCETIN Leaf:
11B-HSD-Inhibitor; 5-Lipoxygenase-Inhibitor IC50 (uM)=4; Aldehyde-Oxidase-Inhibitor IC70-96=10 uM; Aldose-Reductase-Inhibitor 100 uM 4 ug/ml IC50=0.344 uM IC50=0.84 ug/ml cow; Allelochemic IC82=1 mM; Allergenic; Analgesic; Antiaflatoxin IC50=25 uM IC50=7.5 ppm; Antiaggregant 30 uM IC50=55 uM; Antiaging; Antiallergic IC50=14 uM; Antialzheimeran; Antianaphylactic; Antiangiogenic; Antiarthritic; Antiasthmatic; Antiatherosclerotic; Antibacterial; Anticarcinomic (Breast) IC50=1.5 uM; Anticariogenic ID50=120 ug/ml; Anticataract; Anticolitic 400 mg/man/3x/day; Anticomplementary; AntiCrohn's; Anticystitic 1,000 mg/day/4 weeks; Antidepressant; Antidermatitic; Antidiabetic; Antielastase IC50=0.8 ug/ml; Antiencephalitic; Antiescherichic; Antiestrogenic; Antifeedant IC52=<1,000 ppm diet; Antifibrosarcomic; Antiflu; Antigastric; Antigonadotropic; AntiGTF ID50=120 ug/ml; Antihepatotoxic; Antiherpetic 48-150 ug/ml; Antihistaminic IC50=<10 uM; AntiHIV; Antihydrophobic; Antihypertensive; Antiinflammatory 20-150 mg/kg; Antileishmanic IC50=64; Antileukemic 5.5-60 uM IC50=10 uM IC50=>10 ug/ml; Antileukotriene; Antilipoperoxidant IC67=50; Antimalarial IC50=1-6.4 ug/ml; Antimelanomic; Antimetastatic; Antimutagenic ID50=0.62 ug/ml ID50=2-5 nM; Antimyocarditic; Antinitrosaminic; Antinociceptive; Antioxidant 4.7 x Vit. E ED50=2.3 uM IC47=10 uM IC96=300 ppm; Antipancreatitic; Antiperiodontal; Antiperistaltic; Antipermeability; Antiperoxidant; Antipharyngitic; Antiplaque; Antiplasmodial IC50=13-64; AntiPMS 500 mg/2x/day/wmn; Antipodriac; Antipolio; Antiproliferant 10 nM; Antiprostanoid; Antiprostatitic; Antipsoriac; Antiradicular IC50=4.6 uM; Antispasmodic; Antistreptococcic ID50=120 ug/ml; Antithiamin; Antithrombic; Antitrypanosomic IC50=13; Antitumor 10 uM; Antitumor (Bladder); Antitumor (Breast); Antitumor (Colon); Antitumor (Lung); Antitumor (Ovary); Antitumor (Skin) 20 uM; Antitumor-Promoter; Antiulcer; Antiviral 48-150 ug/ml IC50=10 uM; Apoptotic 20-60 uM; ATPase-Inhibitor; Bacteristat 10 mg/ml; Bradycardiac; Calmodulin-Antagonist; cAMP-Phosphodiesterase-Inhibitor; Cancer-Preventive; Candidicide; Capillariprotective; Carcinogenic 40,000 ppm (diet) mus; Catabolic; COMT-Inhibitor; Copper-Chelator; COX-2-Inhibitor <40 uM; Cyclooxygenase-Inhibitor; Cytochrome-P450-1A2-Inhibitor; Cytotoxic ED50=70 ug/ml IC82=100 ug/ml; Deiodinase-Inhibitor; Diaphoretic?; Differentiator 5.5 uM; Estrogenic 10% genistein; Fungicide; Glucosyl-Transferase-Inhibitor ID50=120 ug/ml; Hemostat; Hepatomagenic 5,000 ppm (diet) rat; Hepatoprotective; HIV-RT-Inhibitor IC50=<1 ug/ml; Hypoglycemic 100 mg/kg orl rat; iNOS-Inhibitor IC50=20 uM; Inotropic; Insulinogenic; Juvabional; Larvistat 8,000 ppm diet; Lipoxygenase-Inhibitor IC11=1.25 mM IC50=0.1-5 uM; MAO-A-Inhibitor; Mast-Cell-Stabilizer; Metal-Chelator (Copper); Metalloproteinase-Inhibitor IC50=>42 uM; MMP-9-Inhibitor 20 uM; Mutagenic; NADH-Oxidase-Inhibitor; NEP-Inhibitor IC50=>42 uM; Neuroprotective 5-25 uM; NF-kB-Inhibitor; NO-Inhibitor IC50=20 uM IC>50=125 uM; NO-Synthase-Inhibitor 5-50 uM; Ornithine-Decarboxylase-Inhibitor <10 uM; P450-Inducer 5 uM; P450-Inhibitor 50-100 uM; Pesticide; PGE2-Inhibitor; Phospholipase-Inhibitor; Plasmodicide; Proliferant; Prostaglandin-Synthesis-Inhibitor 40 ug/ml; Protein-Kinase-C-Inhibitor; PTK-Inhibitor 0.4-24 uM; Quinone-Reductase-Inducer 13 uM 6 uM; Teratologic; TNF-alpha-Inhibitor IC50=3.11 uM; Topoisomerase-I-Inhibitor IC50=12.8 ug/ml IC50=42 uM; Topoisomerase-II-Inhibitor IC50=1-6.9 ug/ml IC50=23-40 uM; Tumorigenic 0.1% diet orl rat/yr; Tyrosinase-Inhibitor ID50=70 uM; Tyrosine-Kinase-Inhibitor; Vasodilator; VEGF-Inhibitor; Xanthine-Oxidase-Inhibitor 3.1 uM IC50=10.6 ug/ml IC50=>0.4 ug/ml


ROSMARINIC-ACID Leaf 10,300 - 12,100 ppm Seed 2,300 ppm; Stem 2,900 ppm;
ABeta-Inhibitor; Adenylate-Cyclase-Inhibitor; Aldose-Reductase-Inhibitor; Antiaggregant; Antiallergic; Antialzheimeran; Antianaphylactic 1-100 mg/kg orl ID50=1 mg/kg ivn rat ID50=10 mg/kg ims rat; Antiatherosclerotic IC50=0.74 uM; Antibacterial; Anticoagulant; Anticomplementary 1/2 aspirin 20 mg/kg ivn; Antidepressant; Antiedemic 0.316-3.16 mg/kg ims; Antigonadotropic; Antihemolytic IC70=5-10 um/l; Antihepatotoxic; Antiherpetic 50 ug/ml EC50=20 ug/ml; AntiHIV EC50=40 ug/ml; Antihyperthyroid; Antiinflammatory IC~58=1,000 uM; Antiintegrase 10 ug/ml; Antileukotriene; Antilipoperoxidant; Antimutagenic; Antinephritic; Antioxidant 10 uM EC50=2.7 ug/ml; Antioxidant (LDL) IC50=0.74 uM; Antiplaque; Antiproliferant; Antiprostaglandin 20 mg/kg ivn; Antiproteolytic IC50=0.9 mol l; Antipulmonotic; Antiradicular; Antishock; Antithyreotropic; Antithyroid; Antiuremic; Antiviral EC50=40 ug/ml; Anxiolytic; Apoptotic; Calcium-Antagonist IC50=1.2 uM rbt; Cancer-Preventive; COX-1-Inhibitor IC58=1,000 uM; COX-2-Inhibitor IC>58=1,000 uM; Cytotoxic TC50=100-150 ug/ml; Deiodinase-Inhibitor; Immunomodulator; Immunostimulant; Lipoxygenase-Inhibitor; Neuroprotective; Pesticide; Radioprotective


SCUTELLEREIN Plant:
No activity reported.


XOI-A Plant 11 - 78 ppm
No activity reported.


XOI-B Plant 3 - 21 ppm
No activity reported.


Ubiquitous chemicals not included in analysis
ppm = parts per million
tr = trace

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